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AstraZeneca, Bristol diabetes drug disappoints in key test
LONDON (Reuters) - AstraZeneca and Bristol-Myers Squibb's diabetes drug Onglyza failed to reduce heart risks in a large clinical study, disappointing investors who had thought it might demonstrate an edge over rivals.

Several people killed in northern Yemen bombing: ministry
SANAA (Reuters) - Several people were killed and wounded in Yemen's northern Saada town on Wednesday when a suicide bomber riding a motorbike blew himself up in a busy market, a defence ministry statement said.

A's dismantle Darvish to stretch AL West lead
(Reuters) - The Oakland Athletics overcame Texas Rangers ace Yu Darvish to record a 6-2 road victory on Tuesday to stretch their lead at the top of the American League West division.

Smithfield CEO could make about $46.6 million from Shuanghui deal
(Reuters) - Smithfield Foods Inc Chief Executive Larry Pope could receive nearly $46.6 million in merger-related payments as part of a planned takeover by China's Shuanghui International, a securities filing showed.

Obama to set nuclear arms cut goal in Berlin speech
BERLIN (Reuters) - President Barack Obama will unveil plans for a sharp reduction in nuclear warheads in a landmark speech at the Brandenburg Gate on Wednesday that comes 50 years after John F. Kennedy declared "Ich bin ein Berliner" in a defiant Cold War address.

AstraZeneca, Bristol diabetes drug fails to show heart benefit
LONDON (Reuters) - AstraZeneca and Bristol-Myers Squibb's diabetes drug Onglyza failed to reduce heart risks in a large clinical study.

Allen magic keeps Heat title hopes alive
MIAMI (Reuters) - Ray Allen has made more three pointers than any player in the NBA but with five seconds left and his team three points down on Tuesday, he had not made a single one in the crucial Game Six of the NBA Finals.

Asian markets tense before Fed; Nikkei outperforms
SYDNEY (Reuters) - Japanese stocks rose on Wednesday, thanks to a positive lead from Wall Street and a softer yen, outperforming the rest of Asia which anxiously waited for clarity on the U.S. Federal Reserve's next policy step.

Spurs left to rue missed opportunities against Miami
MIAMI (Reuters) - The San Antonio Spurs were inconsolable after the NBA championship was ripped from their grasp in Tuesday's stunning overtime loss to the Miami Heat.

Heat rally from brink to set up Game Seven decider
MIAMI (Reuters) - The Miami Heat forced an already absorbing NBA Finals to a deciding Game Seven after a thrilling 103-100 overtime victory over the San Antonio Spurs on Tuesday tied the series at 3-3.

New CEO begins Alcatel makeover
PARIS (Reuters) - Telecom equipment maker Alcatel-Lucent will focus on its high-growth fixed and mobile products and slim down via 1 billion euro in cost cuts by 2015 in a bid to reverse years of losses.

North Korean envoy in Beijing seeking to mend ties: experts
BEIJING (Reuters) - A North Korean envoy held talks with Chinese officials on Wednesday that experts said were unlikely to yield concessions from Pyongyang on its nuclear program but were more aimed at repairing ties with Beijing.

Obama to set new goals to cut nuclear weapons: senior official
BERLIN (Reuters) - President Barack Obama will announce on Tuesday he will pursue a new reduction in deployed nuclear weapons, aiming to cut them by up to one third below the level achieved in the last "New START" treaty with Russia, a senior administration official said.

Analysis: French EU-wariness complicates life for Hollande
PARIS (Reuters) - A feeling in France that the European Union no longer works in its interest is fueling tensions between Paris and Brussels and adding pressure on President Francois Hollande to be more assertive in Europe.

After court rules, California gay marriage fight may go on
SAN FRANCISCO (Reuters) - The fight over legalizing gay marriage in the most populous U.S. state may go back to the ballot box in 2014 with California voters asked once again to settle the matter even after the Supreme Court's expected ruling this month on the issue.

Jury selection in Trayvon Martin murder case moves into final phase
SANFORD, Florida (Reuters) - The Florida murder trial to decide the fate of neighborhood watch volunteer George Zimmerman looks to be on track for lawyers to deliver opening statements and witnesses to begin testifying by next Monday.

Fed seen keeping options open on pace of bond buying
WASHINGTON (Reuters) - Federal Reserve policymakers will likely announce on Wednesday that they will keep buying bonds at a monthly pace of $85 billion, while keeping their options open to scale back the program later this year if the U.S. labor market continues to improve.

Fed seen keeping options open on pace of bond buying
WASHINGTON (Reuters) - Federal Reserve policymakers will likely announce on Wednesday that they will keep buying bonds at a monthly pace of $85 billion, while keeping their options open to scale back the program later this year if the U.S. labor market continues to improve.

Rohani once spoke approvingly of hiding Iran atomic work
UNITED NATIONS (Reuters) - Years before he became Iran's president-elect, Hassan Rohani spoke approvingly about concealing his nation's nuclear program and said that when Pakistan got atomic bombs and Brazil began enriching uranium, "the world started to work with them."

U.S. builders complain they can't find skilled carpenters
WASHINGTON (Reuters) - Where have all the carpenters gone? Home builders across the United States are scratching their heads for an answer as they struggle to assemble crews to keep up with growing demand.